If ExFAT is supported in the future, there would be no 4GB file size limit for both Windows and Macintosh computers unlike FAT32. Recent Macintosh and Windows operating systems can format partitions to ExFAT with the use of Disk Utility, Terminal, Disk Management, Command Prompt, etc.
If Damn Small Linux is able to boot from NTFS, Damn Small Linux can be installed to an existing Windows partition without formatting for new Linux users. Ext4 allows more folders and has a higher file size limit when compared to Ext3.